00:00this video is about the science behind this video is about the science behind the whim Hof method and is based on an the whim Hof method and is based on an the whim Hof method and is based on an interview of Ronda petrick and Pierre interview of Ronda petrick and Pierre interview of Ronda petrick and Pierre Capel some of whm Hoff's methods of you Capel some of whm Hoff's methods of you Capel some of whm Hoff's methods of you know breathing and he does some cold know breathing and he does some cold know breathing and he does some cold shock I've been very interested in the shock I've been very interested in the shock I've been very interested in the effects of good types of stress on the effects of good types of stress on the effects of good types of stress on the body so we've been talking about bad body so we've been talking about bad body so we've been talking about bad stress chronic stress but there's also stress chronic stress but there's also stress chronic stress but there's also use stress good stress oh absolutely so use stress good stress oh absolutely so use stress good stress oh absolutely so maybe we could dive in a little bit maybe we could dive in a little bit maybe we could dive in a little bit because I know that you're very because I know that you're very because I know that you're very interested in some of the mechanisms and interested in some of the mechanisms and interested in some of the mechanisms and the science the science the science behind how cold and how these certain behind how cold and how these certain behind how cold and how these certain breathing techniques can change breathing techniques can change breathing techniques can change different hormones you know the endrine different hormones you know the endrine different hormones you know the endrine system immune system oh it changes a lot system immune system oh it changes a lot system immune system oh it changes a lot the point is this to um first of all the point is this to um first of all the point is this to um first of all vhof is a very Charming Man with a lot vhof is a very Charming Man with a lot vhof is a very Charming Man with a lot of stamina and a lot of Charisma and and
01:00of stamina and a lot of Charisma and and of stamina and a lot of Charisma and and he really know how to talk to people to he really know how to talk to people to he really know how to talk to people to convince them that they have to do what convince them that they have to do what convince them that they have to do what they think they should not do like going they think they should not do like going they think they should not do like going into an ice into an ice into an ice BS everyone who just thinks I'm going BS everyone who just thinks I'm going BS everyone who just thinks I'm going into the into the into the ice is a little strange but he convinces ice is a little strange but he convinces ice is a little strange but he convinces please do it and the weird thing is that please do it and the weird thing is that please do it and the weird thing is that people like it and get a positive effect people like it and get a positive effect people like it and get a positive effect and then you say hey how why well if and then you say hey how why well if and then you say hey how why well if you go unprepared into ice cold you go unprepared into ice cold you go unprepared into ice cold water 0° C or whatever it's in water 0° C or whatever it's in water 0° C or whatever it's in finite um you have a lot of pain you get finite um you have a lot of pain you get finite um you have a lot of pain you get a lot of trouble a lot of anxiety it is a lot of trouble a lot of anxiety it is a lot of trouble a lot of anxiety it is terrible don't do it however Vim is terrible don't do it however Vim is terrible don't do it however Vim is training people and they do it and they training people and they do it and they training people and they do it and they like it what what is the training the like it what what is the training the like it what what is the training the training uh is is has two components training uh is is has two components training uh is is has two components first of all uh a medit a meditation
02:00first of all uh a medit a meditation first of all uh a medit a meditation type of thing so you really have to come type of thing so you really have to come type of thing so you really have to come at ease and really uh uh try to get rid at ease and really uh uh try to get rid at ease and really uh uh try to get rid of of all the surrounding of of all the surrounding of of all the surrounding stress and then do this breathing stress and then do this breathing stress and then do this breathing technique the breathing technique itself technique the breathing technique itself technique the breathing technique itself you do about 20 minutes is a type of you do about 20 minutes is a type of you do about 20 minutes is a type of meditation in itself but also a meditation in itself but also a meditation in itself but also a breathing technique so why not have a breathing technique so why not have a breathing technique so why not have a double-edged double-edged double-edged sword sword and um sword sword and um sword sword and um this breeding technique he really this breeding technique he really this breeding technique he really specialized uh in such a way that you specialized uh in such a way that you specialized uh in such a way that you change the content of carbon dioxide in change the content of carbon dioxide in change the content of carbon dioxide in your blood and you lower it carbon your blood and you lower it carbon your blood and you lower it carbon dioxide is is acidic in water and if dioxide is is acidic in water and if dioxide is is acidic in water and if it's out of the bloodstream and the it's out of the bloodstream and the it's out of the bloodstream and the tissue or at least less then the pH is tissue or at least less then the pH is tissue or at least less then the pH is less acidic but more alkaline less acidic but more alkaline
03:00less acidic but more alkaline uh in the normal situation the acid uh in the normal situation the acid uh in the normal situation the acid alkaline balance which is called pH the alkaline balance which is called pH the alkaline balance which is called pH the strict balance is strict balance is strict balance is ph7 and our body is ph7 and our body is ph7 and our body is 7.4 that is our regular situation in the 7.4 that is our regular situation in the 7.4 that is our regular situation in the stomach it's very acidic uh and in that stomach it's very acidic uh and in that stomach it's very acidic uh and in that is this so there is a little difference is this so there is a little difference is this so there is a little difference in the body but let's say 7.4 that is in the body but let's say 7.4 that is in the body but let's say 7.4 that is our our our body uh equivalence of alkaline and body uh equivalence of alkaline and body uh equivalence of alkaline and acid by this breeding acid by this breeding acid by this breeding technique and pumping out a lot of technique and pumping out a lot of technique and pumping out a lot of carbon dioxide and having periods in not carbon dioxide and having periods in not carbon dioxide and having periods in not breathing heavy breeding and well he uh breathing heavy breeding and well he uh breathing heavy breeding and well he uh he can tell people how to do you change he can tell people how to do you change he can tell people how to do you change your your your pH and now comes a little trick that uh pH and now comes a little trick that uh pH and now comes a little trick that uh in his uh training that type of
04:00in his uh training that type of in his uh training that type of uh uh breeding raises the pH sometimes uh uh breeding raises the pH sometimes uh uh breeding raises the pH sometimes to 7.7 to 7.7 to 7.7 7.8 and for biology that is a lot yeah 7.8 and for biology that is a lot yeah 7.8 and for biology that is a lot yeah and this is published this is a and it and this is published this is a and it and this is published this is a and it is published it's is published it's is published it's scientifically uh measured and whatever scientifically uh measured and whatever scientifically uh measured and whatever but we go now back to this uh terrible but we go now back to this uh terrible but we go now back to this uh terrible code if you go uh you always have an code if you go uh you always have an code if you go uh you always have an idea of the temperature of your idea of the temperature of your idea of the temperature of your surrounding and for that you have a surrounding and for that you have a surrounding and for that you have a whole family of uh receptors whole family of uh receptors whole family of uh receptors thermosensors and there's a whole family thermosensors and there's a whole family thermosensors and there's a whole family and for each temperature range you have and for each temperature range you have and for each temperature range you have a separate set of family members who are a separate set of family members who are a separate set of family members who are telling you what the temperature is so telling you what the temperature is so telling you what the temperature is so if it is above 50° Celsius rather hot if it is above 50° Celsius rather hot if it is above 50° Celsius rather hot you will burn so if you touch something you will burn so if you touch something you will burn so if you touch something which is very hot yeah immediately you which is very hot yeah immediately you which is very hot yeah immediately you you can't react differently you can't
05:00you can't react differently you can't you can't react differently you can't keep it on and say smells you don't uh keep it on and say smells you don't uh keep it on and say smells you don't uh but if it is 37° you say h nice and so but if it is 37° you say h nice and so but if it is 37° you say h nice and so there is for each temperature range is a there is for each temperature range is a there is for each temperature range is a family of of temperature sensors which family of of temperature sensors which family of of temperature sensors which are proteins which are doing things and are proteins which are doing things and are proteins which are doing things and they do not only measure temperature but they do not only measure temperature but they do not only measure temperature but also mechanical stress and so if you also mechanical stress and so if you also mechanical stress and so if you feel something uh this touch you feel feel something uh this touch you feel feel something uh this touch you feel it's metal it's colder it is this that it's metal it's colder it is this that it's metal it's colder it is this that is this whole family of things one of is this whole family of things one of is this whole family of things one of the family uh members is uh the family uh members is uh the family uh members is uh effective Beyond 17 17 uh Celsius effective Beyond 17 17 uh Celsius effective Beyond 17 17 uh Celsius soal and uh because our body temperature soal and uh because our body temperature soal and uh because our body temperature doesn't want to be lowered this cold doesn't want to be lowered this cold doesn't want to be lowered this cold surrounding is aggressive we should surrounding is aggressive we should surrounding is aggressive we should avoid it so you get a active stress avoid it so you get a active stress avoid it so you get a active stress response get out of of the cold and now
06:00response get out of of the cold and now response get out of of the cold and now that is this receptor telling you that is this receptor telling you that is this receptor telling you however he's not alone because if you go however he's not alone because if you go however he's not alone because if you go in this cold in this cold in this cold water uh it's painful it's it hurts and water uh it's painful it's it hurts and water uh it's painful it's it hurts and uh you get a very strong anxiety uh you get a very strong anxiety uh you get a very strong anxiety response and I have to get out W and response and I have to get out W and response and I have to get out W and that's so that's so that's so dominating that it really can cause you dominating that it really can cause you dominating that it really can cause you uh a lot of trouble heart attack uh a lot of trouble heart attack uh a lot of trouble heart attack so if you go into ice cold water and you so if you go into ice cold water and you so if you go into ice cold water and you are really in trouble the body is are really in trouble the body is are really in trouble the body is telling you that however pain telling you that however pain telling you that however pain anxiety and temperature they are all anxiety and temperature they are all anxiety and temperature they are all combined in this skinny dipping in the combined in this skinny dipping in the combined in this skinny dipping in the cold water but biologically they are cold water but biologically they are cold water but biologically they are separate units and normally the separate units and normally the separate units and normally the thermosensor tells you it's cold and thermosensor tells you it's cold and thermosensor tells you it's cold and here job of of this
07:00here job of of this here job of of this thermosensor telling you hey switch on thermosensor telling you hey switch on thermosensor telling you hey switch on the heat burn your brown fat generate the heat burn your brown fat generate the heat burn your brown fat generate calories like hell make energy energy calories like hell make energy energy calories like hell make energy energy energy in temperature uh should not drop energy in temperature uh should not drop energy in temperature uh should not drop so burn everything we have to keep your so burn everything we have to keep your so burn everything we have to keep your body temperature constant that is the body temperature constant that is the body temperature constant that is the function of this function of this function of this receptor but it is coupled to a pain receptor but it is coupled to a pain receptor but it is coupled to a pain receptor so be you cannot just sit in receptor so be you cannot just sit in receptor so be you cannot just sit in the water and say oh nice I'm changing the water and say oh nice I'm changing the water and say oh nice I'm changing my metabolism you have pain but now we my metabolism you have pain but now we my metabolism you have pain but now we come to the pain receptor which is come to the pain receptor which is come to the pain receptor which is another one and there's also family of another one and there's also family of another one and there's also family of receptors and the trick is this it is a receptors and the trick is this it is a receptors and the trick is this it is a protein in the protein in the protein in the membrane and as a single protein it's membrane and as a single protein it's membrane and as a single protein it's doing doing doing nothing but if three of these proteins nothing but if three of these proteins nothing but if three of these proteins combine into a trimer so three uh three combine into a trimer so three uh three combine into a trimer so three uh three proteins together in a certain proteins together in a certain proteins together in a certain confirmation
08:00confirmation confirmation then they will signal and that signal is then they will signal and that signal is then they will signal and that signal is pain normal situation like we are pain normal situation like we are pain normal situation like we are sitting here let us say uh that 5% of sitting here let us say uh that 5% of sitting here let us say uh that 5% of our pain receptors are in an active our pain receptors are in an active our pain receptors are in an active state so if I do this well I feel it but state so if I do this well I feel it but state so if I do this well I feel it but doesn't hurt however if I have a big doesn't hurt however if I have a big doesn't hurt however if I have a big wound here and I do this that then we wound here and I do this that then we wound here and I do this that then we get trouble with the neighbors because I get trouble with the neighbors because I get trouble with the neighbors because I shout too shout too shout too loud because then this not 5% is on but loud because then this not 5% is on but loud because then this not 5% is on but everything is in the trimer position and everything is in the trimer position and everything is in the trimer position and generates a pain signal so a paint generates a pain signal so a paint generates a pain signal so a paint signal has a volume uh switch can be low signal has a volume uh switch can be low signal has a volume uh switch can be low can be high but it is dependent on a lot can be high but it is dependent on a lot can be high but it is dependent on a lot of uh things also inflammation but also of uh things also inflammation but also of uh things also inflammation but also on on on ph and at pH ph and at pH ph and at pH 7.7 the pain receptor is a 7.7 the pain receptor is a 7.7 the pain receptor is a monomer so it's it's out so no pain but
09:00monomer so it's it's out so no pain but monomer so it's it's out so no pain but the same receptor is also in the the same receptor is also in the the same receptor is also in the amigdala uh giving fear and pain but amigdala uh giving fear and pain but amigdala uh giving fear and pain but also in the spinal cord and all over also in the spinal cord and all over also in the spinal cord and all over your body so all of a sudden you don't your body so all of a sudden you don't your body so all of a sudden you don't feel pain don't feel anxiety but the feel pain don't feel anxiety but the feel pain don't feel anxiety but the temperature receptor which normally temperature receptor which normally temperature receptor which normally gives you pain in is doing now the job gives you pain in is doing now the job gives you pain in is doing now the job by himself only generates an incredible by himself only generates an incredible by himself only generates an incredible amount of adrenaline gives you energy amount of adrenaline gives you energy amount of adrenaline gives you energy you don't believe burns your fat like you don't believe burns your fat like you don't believe burns your fat like hell and Vim Hof is able to sit for 2 hell and Vim Hof is able to sit for 2 hell and Vim Hof is able to sit for 2 hours or 1 hour and 58 minutes or hours or 1 hour and 58 minutes or hours or 1 hour and 58 minutes or something like that to be precise in ice something like that to be precise in ice something like that to be precise in ice cold water without a significant change cold water without a significant change cold water without a significant change in body temperature why because this in body temperature why because this in body temperature why because this thermos sensor is heating up and burning thermos sensor is heating up and burning thermos sensor is heating up and burning the brown fat come on boys and the brown fat come on boys and the brown fat come on boys and afterwards you're going to change the afterwards you're going to change the afterwards you're going to change the white fat into Brown fat which is the white fat into Brown fat which is the white fat into Brown fat which is the brown fat is in this area of your body
10:00brown fat is in this area of your body brown fat is in this area of your body and uh so you regenerate that and so if and uh so you regenerate that and so if and uh so you regenerate that and so if you come into the cold you get a you come into the cold you get a you come into the cold you get a fantastic amount of energy you get this fantastic amount of energy you get this fantastic amount of energy you get this strong stress response without pain and strong stress response without pain and strong stress response without pain and fear and then you can walk up a fear and then you can walk up a fear and then you can walk up a mountain in short time what's the name mountain in short time what's the name mountain in short time what's the name of the thermal receptor do you know the of the thermal receptor do you know the of the thermal receptor do you know the uh yes that is uh yes that is uh yes that is uh um transient potential t TP oh one of uh um transient potential t TP oh one of uh um transient potential t TP oh one of the tpv or RV yeah tpv a whole family the tpv or RV yeah tpv a whole family the tpv or RV yeah tpv a whole family yeah I the names it's uh responding to yeah I the names it's uh responding to yeah I the names it's uh responding to the cold and and and there are also the cold and and and there are also the cold and and and there are also receptors uh which are responding to receptors uh which are responding to receptors uh which are responding to heat and whatever right yeah so um have heat and whatever right yeah so um have heat and whatever right yeah so um have so many questions but one is the so many questions but one is the so many questions but one is the importance between coupling importance between coupling importance between coupling the breathing technique which then the breathing technique which then the breathing technique which then decreases the carbon oxide in the blood
11:00decreases the carbon oxide in the blood decreases the carbon oxide in the blood and there as a consequence raises right and there as a consequence raises right and there as a consequence raises right but it raises the blood uh pH to a but it raises the blood uh pH to a but it raises the blood uh pH to a little more alkaline which by the way is little more alkaline which by the way is little more alkaline which by the way is not easy to do usually you can't just not easy to do usually you can't just not easy to do usually you can't just raise your your pH of your blood but C raise your your pH of your blood but C raise your your pH of your blood but C you know breathing obvious the breathing you know breathing obvious the breathing you know breathing obvious the breathing techniques obviously it's it's it's techniques obviously it's it's it's techniques obviously it's it's it's working and and that's been published um working and and that's been published um working and and that's been published um and that then switches off the the the and that then switches off the the the and that then switches off the the the recept the pain receptor which needs to recept the pain receptor which needs to recept the pain receptor which needs to be trimerized so it's now not able to do be trimerized so it's now not able to do be trimerized so it's now not able to do that because the pH is too high that because the pH is too high that because the pH is too high so that's uncoupling now the pain so that's uncoupling now the pain so that's uncoupling now the pain receptor from the thermo receptor which receptor from the thermo receptor which receptor from the thermo receptor which somehow I know that ucp1 the uncoupling somehow I know that ucp1 the uncoupling somehow I know that ucp1 the uncoupling protein which nor epinephrine which is protein which nor epinephrine which is protein which nor epinephrine which is cold releases norepinephrine and that cold releases norepinephrine and that cold releases norepinephrine and that activates uncoupling protein one which activates uncoupling protein one which activates uncoupling protein one which then uncouples your mitochondria so your then uncouples your mitochondria so your then uncouples your mitochondria so your mitochondria usually are sensing you mitochondria usually are sensing you mitochondria usually are sensing you know the electrochemical gradient and know the electrochemical gradient and know the electrochemical gradient and when that becomes uncoupled your when that becomes uncoupled your when that becomes uncoupled your mitochondria go oh my God I need to make mitochondria go oh my God I need to make mitochondria go oh my God I need to make energy so they burning more you know energy so they burning more you know energy so they burning more you know you're basically burning all the energy
12:00you're basically burning all the energy you're basically burning all the energy like you said to uh you know generate like you said to uh you know generate like you said to uh you know generate heat and to also make energy ATP so you heat and to also make energy ATP so you heat and to also make energy ATP so you end up burning fat like you said um and end up burning fat like you said um and end up burning fat like you said um and that this is all really cool because I that this is all really cool because I that this is all really cool because I was for one the the pH changing the pH was for one the the pH changing the pH was for one the the pH changing the pH of the blood I was not I was a little of the blood I was not I was a little of the blood I was not I was a little skeptical of that until I actually read skeptical of that until I actually read skeptical of that until I actually read the study and um and how you know carbon the study and um and how you know carbon the study and um and how you know carbon dioxide in the blood can do that I think dioxide in the blood can do that I think dioxide in the blood can do that I think there's a term for it like respiratory there's a term for it like respiratory there's a term for it like respiratory alkalosis or something oh yeah you can alkalosis or something oh yeah you can alkalosis or something oh yeah you can name it whatever yeah but the point is name it whatever yeah but the point is name it whatever yeah but the point is it's functional yeah yeah have you have it's functional yeah yeah have you have it's functional yeah yeah have you have you tried any of the breathing you tried any of the breathing you tried any of the breathing techniques or well uh no not in that techniques or well uh no not in that techniques or well uh no not in that sense that um but I have a little story sense that um but I have a little story sense that um but I have a little story I know a guy who was doing this for the I know a guy who was doing this for the I know a guy who was doing this for the first time and he didn't take this first time and he didn't take this first time and he didn't take this breeding so serious so I said well I
13:00breeding so serious so I said well I breeding so serious so I said well I should okay and in the meantime should okay and in the meantime should okay and in the meantime wandering around and then hopped into wandering around and then hopped into wandering around and then hopped into the cold water and that was extremely the cold water and that was extremely the cold water and that was extremely unpleasant and then the second unpleasant and then the second unpleasant and then the second time uh he really was aware hey I should time uh he really was aware hey I should time uh he really was aware hey I should take it serious this breathing and then take it serious this breathing and then take it serious this breathing and then he had no trouble so this is a control he had no trouble so this is a control he had no trouble so this is a control in itself so the breathing technique is in itself so the breathing technique is in itself so the breathing technique is really necessary to prepare for this really necessary to prepare for this really necessary to prepare for this cold and this cold will after uncoupling cold and this cold will after uncoupling cold and this cold will after uncoupling of all the other effects will have the of all the other effects will have the of all the other effects will have the positive uh stress response in positive uh stress response in positive uh stress response in metabolism adrenaline and Etc without metabolism adrenaline and Etc without metabolism adrenaline and Etc without the pain so you can withstand the cold the pain so you can withstand the cold the pain so you can withstand the cold for longer yes I've been very interested for longer yes I've been very interested for longer yes I've been very interested in the effects of temperature on um on in the effects of temperature on um on in the effects of temperature on um on the human physiology I've talked a lot the human physiology I've talked a lot the human physiology I've talked a lot about the sauna and how the sauna is a a about the sauna and how the sauna is a a about the sauna and how the sauna is a a good hormetic stress activates heat good hormetic stress activates heat good hormetic stress activates heat shock proteins which have a variety of shock proteins which have a variety of shock proteins which have a variety of positive effects it also uh changes positive effects it also uh changes positive effects it also uh changes brain brain function as well um it brain brain function as well um it brain brain function as well um it changes the opioid system endorphins
14:00changes the opioid system endorphins changes the opioid system endorphins makes you more sensitive to them so I makes you more sensitive to them so I makes you more sensitive to them so I became very interested in that um but became very interested in that um but became very interested in that um but cold more recently I became interested cold more recently I became interested cold more recently I became interested um because there was a paper that was um because there was a paper that was um because there was a paper that was published in nature last January where published in nature last January where published in nature last January where researchers took mice and exposed them researchers took mice and exposed them researchers took mice and exposed them to about 4° C for 45 minutes caus their to about 4° C for 45 minutes caus their to about 4° C for 45 minutes caus their core body temperature so unlike whim core body temperature so unlike whim core body temperature so unlike whim their core body temperature dropped from their core body temperature dropped from their core body temperature dropped from you know 98.6 to about 65 you know 98.6 to about 65 you know 98.6 to about 65 5° Fahrenheit um so very hypothermia 5° Fahrenheit um so very hypothermia 5° Fahrenheit um so very hypothermia almost but what was very interesting is almost but what was very interesting is almost but what was very interesting is that they the cold chock there's a a that they the cold chock there's a a that they the cold chock there's a a whole class of proteins called cold whole class of proteins called cold whole class of proteins called cold chock proteins that are activated by the chock proteins that are activated by the chock proteins that are activated by the cold and one of them specifically is in cold and one of them specifically is in cold and one of them specifically is in uh the brain and at the dendritic spine uh the brain and at the dendritic spine uh the brain and at the dendritic spine region of neurons and it increases region of neurons and it increases region of neurons and it increases dramatically in the cold and what's dramatically in the cold and what's dramatically in the cold and what's really interesting is that what the really interesting is that what the really interesting is that what the function of this protein is is rbm3 is
15:00function of this protein is is rbm3 is function of this protein is is rbm3 is to regrow lost synapses so hibernating to regrow lost synapses so hibernating to regrow lost synapses so hibernating animals bears for example you know some animals bears for example you know some animals bears for example you know some hibernating rodents when they go into hibernating rodents when they go into hibernating rodents when they go into hibernation they lose a significant hibernation they lose a significant hibernation they lose a significant amount of their synapses I forgot like amount of their synapses I forgot like amount of their synapses I forgot like 30 or 40% or something like that but 30 or 40% or something like that but 30 or 40% or something like that but when they come out of the hibernation when they come out of the hibernation when they come out of the hibernation they regrow the synapses that they lost they regrow the synapses that they lost they regrow the synapses that they lost which has huge implications of course which has huge implications of course which has huge implications of course for gener of disease brain Aging in for gener of disease brain Aging in for gener of disease brain Aging in general uh so so this is kind of what general uh so so this is kind of what general uh so so this is kind of what instigated the study because they found instigated the study because they found instigated the study because they found that what happens is upon hibernation that what happens is upon hibernation that what happens is upon hibernation they have this huge increase in this they have this huge increase in this they have this huge increase in this Gene in the brain rbm3 and that Gene in the brain rbm3 and that Gene in the brain rbm3 and that regulates you know regrowing the regulates you know regrowing the regulates you know regrowing the synapsis so uh that's when I became very synapsis so uh that's when I became very synapsis so uh that's when I became very interested in the cold and then started interested in the cold and then started interested in the cold and then started reading about it and all the effects on reading about it and all the effects on reading about it and all the effects on the endocrine system nephrine burning of the endocrine system nephrine burning of the endocrine system nephrine burning of the metabolism and now I'm very the metabolism and now I'm very the metabolism and now I'm very interested in some of the techniques interested in some of the techniques interested in some of the techniques that whims doing and the science behind that whims doing and the science behind that whims doing and the science behind what's going on so I'm really excited to what's going on so I'm really excited to what's going on so I'm really excited to have you talk about about it and um so
16:00have you talk about about it and um so have you talk about about it and um so but you wanted to talk about a couple of but you wanted to talk about a couple of but you wanted to talk about a couple of other interesting effects on the same other interesting effects on the same other interesting effects on the same family of receptor yes and then we don't family of receptor yes and then we don't family of receptor yes and then we don't go so bizarre as in the Heat or in the go so bizarre as in the Heat or in the go so bizarre as in the Heat or in the cold or whatever but we just go to this cold or whatever but we just go to this cold or whatever but we just go to this family of family of family of receptors uh which uh the family name is receptors uh which uh the family name is receptors uh which uh the family name is trp and then uh you have Uncle M and RTV trp and then uh you have Uncle M and RTV trp and then uh you have Uncle M and RTV and uh so the whole family is rtpv one and uh so the whole family is rtpv one and uh so the whole family is rtpv one or M or M or M Etc uh the question is that you have a Etc uh the question is that you have a Etc uh the question is that you have a measurement of each type of temperature measurement of each type of temperature measurement of each type of temperature by each family member but now the by each family member but now the by each family member but now the question is why in the tropics people question is why in the tropics people question is why in the tropics people eat so spicy a lot of hot peppers the eat so spicy a lot of hot peppers the eat so spicy a lot of hot peppers the point is this that um a compound with a point is this that um a compound with a point is this that um a compound with a beautiful name in uh the red pepper is beautiful name in uh the red pepper is beautiful name in uh the red pepper is binding to one of these family members binding to one of these family members binding to one of these family members which senses Heat not the extreme heat
17:00which senses Heat not the extreme heat which senses Heat not the extreme heat not 50 but so around 40 de not 50 but so around 40 de not 50 but so around 40 de Cel or so around 100 100 Cel or so around 100 100 Cel or so around 100 100 trite what is doing that the pepper trite what is doing that the pepper trite what is doing that the pepper stimulates this receptor so the receptor stimulates this receptor so the receptor stimulates this receptor so the receptor SS you are too hot caps is that SS you are too hot caps is that SS you are too hot caps is that specifically that is the the name but uh specifically that is the the name but uh specifically that is the the name but uh the receptor senses HS hot and is the receptor senses HS hot and is the receptor senses HS hot and is reducing your body temperature to reducing your body temperature to reducing your body temperature to neutralize the effect of the outside neutralize the effect of the outside neutralize the effect of the outside temperature so you lower your body temperature so you lower your body temperature so you lower your body temperature by spicy food but if you're temperature by spicy food but if you're temperature by spicy food but if you're in the tropics you will be heated up by in the tropics you will be heated up by in the tropics you will be heated up by the Sun and if I go as a Westerner not the Sun and if I go as a Westerner not the Sun and if I go as a Westerner not well I like spicy food but I haven't well I like spicy food but I haven't well I like spicy food but I haven't done it and walk there I'm sweating and done it and walk there I'm sweating and done it and walk there I'm sweating and then you have this really White Man's then you have this really White Man's then you have this really White Man's Burden in the Burden in the Burden in the tropical you know that well sorry but um tropical you know that well sorry but um tropical you know that well sorry but um whereas if you have spicy food you lower whereas if you have spicy food you lower whereas if you have spicy food you lower your body temperature the sun is Raising
18:00your body temperature the sun is Raising your body temperature the sun is Raising it but to the normal level you want and it but to the normal level you want and it but to the normal level you want and you don't have to sweat to get rid of you don't have to sweat to get rid of you don't have to sweat to get rid of the extra temperature because you set the extra temperature because you set the extra temperature because you set your thermostat lower so that is what your thermostat lower so that is what your thermostat lower so that is what the hot pepper is doing now the other the hot pepper is doing now the other the hot pepper is doing now the other way the cold receptor if you have a cold way the cold receptor if you have a cold way the cold receptor if you have a cold you have all these type of uh things you have all these type of uh things you have all these type of uh things that you wrap your breast with mental or that you wrap your breast with mental or that you wrap your breast with mental or eucalyptus Etc the point is that eucalyptus Etc the point is that eucalyptus Etc the point is that compounds from these plants bind to the compounds from these plants bind to the compounds from these plants bind to the cold receptor so as soon as you rub in cold receptor so as soon as you rub in cold receptor so as soon as you rub in your chest it feels cold because you your chest it feels cold because you your chest it feels cold because you sense cold like the pepper you feel hot sense cold like the pepper you feel hot sense cold like the pepper you feel hot but um that temperature receptor is not but um that temperature receptor is not but um that temperature receptor is not only making more energy and whatever but only making more energy and whatever but only making more energy and whatever but changing the blood flow so the blood changing the blood flow so the blood changing the blood flow so the blood flow increases in this area where you flow increases in this area where you flow increases in this area where you put mental or put mental or put mental or eucalyptus and you generate heat so eucalyptus and you generate heat so eucalyptus and you generate heat so first is cold and then it really is first is cold and then it really is first is cold and then it really is getting warm because you pump up the
19:00getting warm because you pump up the getting warm because you pump up the fire by this plant uh extract and the fire by this plant uh extract and the fire by this plant uh extract and the the trick with cold why it's so good and the trick with cold why it's so good and the trick with cold why it's so good and very simple and you don't need further very simple and you don't need further very simple and you don't need further medication because you can do it medication because you can do it medication because you can do it yourself is what is a common cold if I yourself is what is a common cold if I yourself is what is a common cold if I am for 10 minutes outside and am for 10 minutes outside and am for 10 minutes outside and unprotected and I feel cold tomorrow I'm unprotected and I feel cold tomorrow I'm unprotected and I feel cold tomorrow I'm Ill how's that possible the point is Ill how's that possible the point is Ill how's that possible the point is that this illness is already there but I that this illness is already there but I that this illness is already there but I can cope with it so you have a Reno can cope with it so you have a Reno can cope with it so you have a Reno virus or whatever cause of my common virus or whatever cause of my common virus or whatever cause of my common cold and my immune system is coping with cold and my immune system is coping with cold and my immune system is coping with it so let's say I have 100 uh units of it so let's say I have 100 uh units of it so let's say I have 100 uh units of immunity which have to fight to 80 units immunity which have to fight to 80 units immunity which have to fight to 80 units of a viral or whatever infection so the of a viral or whatever infection so the of a viral or whatever infection so the immune system dominates the Infectious immune system dominates the Infectious immune system dominates the Infectious agent and this is a continuous process agent and this is a continuous process agent and this is a continuous process now I go 10 minutes into the now I go 10 minutes into the now I go 10 minutes into the cold the blood flow changes because the cold the blood flow changes because the cold the blood flow changes because the cold gives fast rest friction so you cold gives fast rest friction so you cold gives fast rest friction so you have less blood so my 100 units per time
20:00have less blood so my 100 units per time have less blood so my 100 units per time can't reach that place and become can't reach that place and become can't reach that place and become 75 hey says the the virus 75 hey says the the virus 75 hey says the the virus poof and um because that goes very fast poof and um because that goes very fast poof and um because that goes very fast um half a day or a day later you have a um half a day or a day later you have a um half a day or a day later you have a common cold so if you now put on uh some common cold so if you now put on uh some common cold so if you now put on uh some mental or mental or mental or eucalyptus by increasing the blood flow eucalyptus by increasing the blood flow eucalyptus by increasing the blood flow and giving a lot of energy and the and giving a lot of energy and the and giving a lot of energy and the temperature then the immune system comes temperature then the immune system comes temperature then the immune system comes back with much more units per time than back with much more units per time than back with much more units per time than the hund and can cope with it and so the hund and can cope with it and so the hund and can cope with it and so therefore these simple uh things from therefore these simple uh things from therefore these simple uh things from plants have a very strong effect I never plants have a very strong effect I never plants have a very strong effect I never knew there was actually any validity knew there was actually any validity knew there was actually any validity behind putting Menthol or eucalyptus oil behind putting Menthol or eucalyptus oil behind putting Menthol or eucalyptus oil but you feel it out cold and a worm but you feel it out cold and a worm but you feel it out cold and a worm and I don't remember like you know it's and I don't remember like you know it's and I don't remember like you know it's been so long I was a kid I think my mom been so long I was a kid I think my mom been so long I was a kid I think my mom put it on my chest when I was sick but I
21:00put it on my chest when I was sick but I put it on my chest when I was sick but I you know it's been just it's been you know it's been just it's been you know it's been just it's been decades since I've done it so I don't decades since I've done it so I don't decades since I've done it so I don't remember feeling remember feeling remember feeling warm well you can do it now maybe yeah warm well you can do it now maybe yeah warm well you can do it now maybe yeah kind of a burning feeling that so okay kind of a burning feeling that so okay kind of a burning feeling that so okay let me ask you this then why why when let me ask you this then why why when let me ask you this then why why when you go out in the cold don't you have you go out in the cold don't you have you go out in the cold don't you have the same response so obviously there's the same response so obviously there's the same response so obviously there's ve Vaso contriction occurring um how ve Vaso contriction occurring um how ve Vaso contriction occurring um how come there's not a response then also come there's not a response then also come there's not a response then also similarly to then increase the blood similarly to then increase the blood similarly to then increase the blood flow after or is there flow after or is there flow after or is there well the point is that if you go into well the point is that if you go into well the point is that if you go into the real cold like whim is doing you the real cold like whim is doing you the real cold like whim is doing you switch on fullblown all the engines to switch on fullblown all the engines to switch on fullblown all the engines to pump up the pump up the pump up the fire but if I walk out here and I go fire but if I walk out here and I go fire but if I walk out here and I go from room temperature to a little lower from room temperature to a little lower from room temperature to a little lower I don't have this family member which is I don't have this family member which is I don't have this family member which is reacting at reacting at reacting at -17 my throat is getting minus -17 my throat is getting minus -17 my throat is getting minus 24 so I don't activate the receptor whim
22:0024 so I don't activate the receptor whim 24 so I don't activate the receptor whim is using which pumps up the whole thing is using which pumps up the whole thing is using which pumps up the whole thing I see and I do with mental I go to the I see and I do with mental I go to the I see and I do with mental I go to the low temperature receptor which I pump up low temperature receptor which I pump up low temperature receptor which I pump up the activity so a decrease in the activity so a decrease in the activity so a decrease in temperature from 37 to 28 so in your temperature from 37 to 28 so in your temperature from 37 to 28 so in your fingers it it can be 28 or so uh that fingers it it can be 28 or so uh that fingers it it can be 28 or so uh that doesn't switch on the receptor which doesn't switch on the receptor which doesn't switch on the receptor which viim is using in the cold B so you have viim is using in the cold B so you have viim is using in the cold B so you have to go much further so if you go uh into to go much further so if you go uh into to go much further so if you go uh into the eyes paath you immediately trigger the eyes paath you immediately trigger the eyes paath you immediately trigger the subsequent uh response if you just the subsequent uh response if you just the subsequent uh response if you just walk outside uh and you are just chil or walk outside uh and you are just chil or walk outside uh and you are just chil or whatever you you do not have the proper whatever you you do not have the proper whatever you you do not have the proper family member of the receptor being family member of the receptor being family member of the receptor being activated mhm so we need to also be activated mhm so we need to also be activated mhm so we need to also be happy when we go outside when it's cold happy when we go outside when it's cold happy when we go outside when it's cold because being happy also regulates our because being happy also regulates our because being happy also regulates our response to this virus and whether or response to this virus and whether or response to this virus and whether or not we're going to fight it off oh yeah not we're going to fight it off oh yeah not we're going to fight it off oh yeah and so it is really and so it is really and so it is really important uh to have a positive view on
23:00important uh to have a positive view on important uh to have a positive view on life and there are a lot of studies of life and there are a lot of studies of life and there are a lot of studies of people who are optimistic or people who are optimistic or people who are optimistic or pessimistic and that really makes a pessimistic and that really makes a pessimistic and that really makes a difference statistically in how they difference statistically in how they difference statistically in how they cope with diseases life expectance the cope with diseases life expectance the cope with diseases life expectance the number of days without disease that is number of days without disease that is number of days without disease that is directly related to a positive or directly related to a positive or directly related to a positive or negative uh attitude to life