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The Paradox of IGF-1: Rethinking Diets for Longevity and Healthspan
02 Rhonda Patrick Ph D paradox of IGF 1 ketogenic diets and genetics benefits of
Key Takeaways
Dr. Rhonda Patrick discusses the paradox of IGF-1 and its relationship with health and longevity.
Caloric restriction may not be the best method for increasing healthspan; periods of growth are also important.
Recent studies show ketogenic diets can improve lifespan and cognitive function in animal models.
Genetics may explain why some individuals respond poorly to ketogenic diets.
The importance of nutrient density in diets, particularly in ketogenic approaches, is emphasized.
Flexibility in beliefs about dietary practices is crucial for scientific understanding.
30%
Caloric restriction suggested for increasing healthspan.
11-12 years
Median lifespan of lemurs studied in relation to caloric restriction.
4500
Calories needed daily for maintaining weight on a ketogenic diet.
Introduction and Background
Peter Atia introduces Dr. Rhonda Patrick and their shared interests.
Discussion about the evolution of beliefs in dietary practices.
IGF-1 and Growth Hormone
Exploration of IGF-1's role in healthspan and its paradoxical effects.
Importance of balancing caloric restriction with periods of growth.
Ketogenic Diets
Discussion on the effectiveness of ketogenic diets for health and longevity.
Genetic factors influencing individual responses to ketogenic diets.
Nutrient Density and Dietary Practices
Importance of including nutrient-dense foods in diets.
Skepticism about the long-term health effects of strict ketogenic diets.
Flexibility in Scientific Beliefs
The necessity of adapting beliefs based on new scientific evidence.
Personal anecdotes about changing views on dietary practices.
Notable Quotes
"One of the major modalities for increasing healthspan would be calorie restriction or dietary restriction."
"I think that periods of growth are really important."
"Flexibility in beliefs about dietary practices is crucial for scientific understanding."